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The objectives of currently funded research are to explore and
characterize the oxidative regulation, via H2O2, of protein
phosphatases such as PTEN and others linked to the PI3k/akt survival
pathway in bcr-abl expressing cells and thus increase our understanding
of cell survival in leukemia.
We will also investigate the role played by the NADPH oxidase system in
the generation of H2O2. We will use the oxygen/nitrogen radical
scavenger CR-6
(3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1(2H)-benzopyran) a
?-tocopherol derivative see if we can block the effects of H2O2 and
thus reduce cell survival signalling through the PI3k/akt pathway and
make cells more susceptible to apoptosis. This may facilitate a
possible future therapeutic avenue. Finally, we would like to extend
the work to patient cells to validate model system used in the study.
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