The main thrust of our work is to explore the regulation of programmed cell death (apoptosis) in the genesis and progression of leukaemia.  To this end we have focused on the role the bcr-abl and related genes that are potent inhibitors of apoptosis and contributes significantly to the survival of leukaemia cells. Continue...

A study funded by the Children's Leukaemia Research Project (CLRP) involving a collaboration between St James's Hospital, Trinity College Dublin and Our Lady's Hospital for Sick Children in Crumlin has yielded exciting results in relation to the use of molecular biology to aid in patient management for children with leukaemia. Continue...